| 학회 |
한국고분자학회 |
| 학술대회 |
2022년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
47권 1호 |
| 발표분야 |
콜로이드 및 분자조립 부문위원회 |
| 제목 |
Ion-Selective Artificial Membrane-Incorporated Hydrogel Ionic Transistor for Real-Time K+ Signal Monitoring |
| 초록 |
Toward next-generation high-performance biosensors, target-selective signal amplification capability must be fulfilled, which can be achieved by introducing molecular filtration membranes. Typical physical filters cannot guarantee the target selectivity in body fluids because many other molecules of similar size cannot be distinguished. To solve this problem, we aimed to rely on molecular recognition, and in this work, we newly developed a biological membrane-inspired K+-selective membrane as a model system. We created artificial K+ channels by hydrophobically modifying G-quadruplexes that contain K+ binding motifs. Through the channel-embedded membrane, anion transport was perfectly blocked, and K+-preferred ion transport among similar-sized alkali metal ions was accomplished. When the K+-selective membrane was introduced to the hydrogel ionic transistor, a novel K+ real-time monitoring sensor was successfully fabricated which can also detect K+ signal changes even in body fluids. |
| 저자 |
유혜빈1, 강순보2, 박건웅3, 유현재2, 임현호3, 선정윤2, 오승수1
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| 소속 |
1포항공과대, 2서울대, 3한국뇌(연) |
| 키워드 |
Ion-selective membrane; Artificial ion channel; Hydrogel ionic transistor; Real-time ion signal monitoring
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| E-Mail |
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