| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 봄 (04/10 ~ 04/11, 컨벤션 뷰로(대전)) |
| 권호 |
33권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Precise Preparation of Four-arm Poly(ethyleneglycol) -b- Poly(trimethylene carbonate) Star Block Copolymers via Activated Monomer Mechanism and Examination of Their Solution Properties |
| 초록 |
The polymerization of trimethylene carbonate (TMC) in the presence of HCl·Et2O via activated monomer mechanism was performed to synthesize 4a-PEG-b-PTMC star block copolymers composed of poly(ethylene glycol) (PEG) and poly(trimethylene carbonate) (PTMC) using 4 arm (4a) PEG as an initiator. We prepared successfully 4a-PEG-b-PTMC star block copolymers without metal catalyst at room temperature via living ring-opening polymerization (ROP) of TMC from 4a PEG as an initiator in the presence of HCl·Et2O as a monomer activator. The CMCs of the 4a-PEG-b-PTMC star block copolymers determined from fluorescence measurements. The CMCs of the 4a-PEG-b-PTMC star block copolymers decreased in the order of the increase in the PTMC segment. In conclusion, we confirmed that the 4a-PEG-b-PTMC star block copolymers form micelles and hence may be potential hydrophobic drug delivery vehicles. |
| 저자 |
조재송1, 김병수1, 윤주용2, 오재민1, 김문석1, 고재훈3, 박영환3, 강길선2, 이해방1
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| 소속 |
1한국화학(연), 2전북대, 3한국생산기술(연) |
| 키워드 |
poly(ethylene glycol); poly(trimethylene carbonate); star block copolymer; activated monomer mechanism; micelle.
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| E-Mail |
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