| 초록 |
In this presentation, we designed and synthesized a mucosal vaccine delivery system based on biosynthetic poly (γ-glutamic acid) (γ-PGA)-based nanomicelle. The research results suggested that the modification of γ-PGA nanomicelles with amines is critical in order for inducing strong interactions with the anionic epithelial cell layer that leads to efficient antigen delivery, although the carboxylic groups of γ-PGA can act as mucoadhesives by interacting with the hydroxyl groups of the glycoproteins of the mucus layer. When OVA (as a model protein antigen) or PR8 (as an influenza A viral antigen: H1N1) were co-delivered intranasally with polymer nanomicelles, they strongly induced antigen-specific antibody production and IFN-γ-producing cells, suggesting that the polymer nanomicelle system could function as an effective adjuvant that potently induces both humoral and cellular immune responses. |
