| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 가을 (10/09 ~ 10/10, 일산킨텍스) |
| 권호 |
33권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Simultaneously Self-assembled Fluorescent Magnetic Nanoprobes for Multimode-Biomedical Imaging |
| 초록 |
Fluorescent magnetic nanoprobes (FMNPs) were fabricated with amphiphilic pyrenyl polyethylene glycol (Py-PEG) and monodispersed superparamagnetic MnFe2O4 (MNCs) for application as multimodal (MR and fluorescence) imaging probes by a nano-emulsion method. Py-PEG as an amphiphilic fluorescent surfactant was formed by conjugating hydrophilic PEG with hydrophobic and fluorescent 1-pyrenebutyric acid through esterification process. Py-PEG was able to be self-assembled in aqueous phase and maintained high fluorescent intensity. FMNPs were maintained superparamagnetism of MNCs and fluorescence of Py-PEG simultaneously. Furthermore, the NIH 3T6.7 cells treated with FMNPs were detected through MR and fluorescence imaging. Therefore, FMNPs were verified a sufficient sensitivity to external magnetic fields and fluorescence properties to serve as nanoprobes for multimode biomedical imaging. |
| 저자 |
임은경, 함승주, 양재문, 허용민, 서진석
|
| 소속 |
연세대 |
| 키워드 |
multimodal imaging agent; MR; fluorescence; biomedical
|
| E-Mail |
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