| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 가을 (10/07 ~ 10/08, 대구 EXCO) |
| 권호 |
35권 2호 |
| 발표분야 |
대학원생 구두발표 |
| 제목 |
Gold Nanorod-Loaded, Chitosan-Conjugated Nano-Carriers for In-Vitro Photothermal Cancer Therapy |
| 초록 |
Previously, we reported Pluronic-based nano-carriers (bare forms and chitosan-conjugated forms) which possess excellent reservoir characteristics with a simple loading method and a high loading capacity of large molecules as drug delivery systems. These nano-carriers were employed as carriers of gold nanorods (GNR). The GNR-loaded nano-carriers could serve as an imaging agent for cancer (SCC7) cells and a hyperthermia agent with improved photothermal cancer therapy in the NIR region. The GNR-loaded nano-carriers showed improved in-vitro photothermolysis of cancer cells as well as in-vitro stability of GNRs compared to GNRs themselves. Specially, the GNR-loaded nano-carriers using chitosan forms were much more efficient and selective for cancer cell uptake and damaging by an NIR laser compared to bare GNRs. Acknowledgement: This research was partially supported by NRF NCRC grant (R15-2008-006-02002-0) and WCU program (R31-2008-000-10026-0), MEST, Korea. |
| 저자 |
최원일1, 김자영1, 강철2, 변지수3, 김영하1, 태기융1
|
| 소속 |
1광주과학기술원 신소재공학부 및 나노바이오재료전자공학과, 2광주과학기술원 고등광기술원, 3경북대 |
| 키워드 |
Pluronic; nano-hydrogel; gold nanorods; photothermal therapy
|
| E-Mail |
|
