| 초록 |
The analytical performances of electrochemical sensors have been improved by adopting various nanomaterials. Electrodes with nanoscale structures can facilitate electrochemical reactions via nanoconfinement effect and subsequently increase the sensing signals, which has been limitedly applied to several reactions. To broaden the applicability of such effect, we designed an electrochemical reaction path that can cycle in the nanoscale inner space of an electrode and consequently lead to significant improvement in measurement sensitivity. This path utilizes redox-cycling reaction that is mediated by the redox capacitor molecules tethered to the electrode surface. By controlling the nanostructure and functionalization of the electrode, it was possible to substantially amplify the electrochemical signals and detect the electroactive molecules (here, we used a molecular biomarker of bacterial infection) with improved sensitivity. This work shows a unique method of utilizing the nanoconfinement effect and enlarges the applicability of various nanomaterials in biosensors. |
