| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Nanocoupling by surface-initiated ring opening polymerization of L-lactide onto metal for improved stable adhesionof stents |
| 초록 |
Generally, the delamination of the sub-micrometer scale between polymeric layer and the surface occurred after grafting a polymeric layer containing drug onto metal surface such as stents. This separation inhibits strong interfacial adhesion between them, leading to unstable state in their adhesion. We introduced nanocoupling concept by the grafting method such as surface-initiated polymerization (SIP) for solving this problem. L-lactide (LA) was grafted by surface initiated-ring opening polymerization (SI-ROP) from the hydroxyl group generated by oxygen-plasma discharge on stainless steel, served as for removing of a separation between polymeric layers and metal surface. Subsequently, poly(L-lactide-co-glycolide acid) (PLGA) solution is coated onto the polymeric layer-grafted metal surface by electrospraying for fabricating robust and bulky film for drug eluting stent (DES), and their characteristics were examined. |
| 저자 |
조성배1, 이봉수1, 박귀덕1, 정동준2, 한동근1
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| 소속 |
1한국과학기술(연), 2성균관대 |
| 키워드 |
stent; ring opening polymerization; L-Lactide; nanocoupling
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| E-Mail |
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