| 초록 |
A novel type of antimicrobial agents based on a more straight-forward sterilizing mechanism to minimize the risk of bacteria developing resistant traits is thus highly desirable. Here, we present a facile and scalable approach to synthesize various architecturally nanoengineered antimicrobial polypeptides (ANAPs), including linear-, hinged-, star-, and cyclic-poly(L-lysine)-random-poly(γ-benzyl-L-glutamate) (Kx-r-BQy) with different K to BQ ratios. Linear-, hinged-, and star-ANAPs are easily accessible by imidazolium hydrogen carbonates-organocatalyzed fast polymerization of Nε-tert-butyloxycarbonyl-L-lysine N-carboxyanhydrides (BLL NCA) and γ-benzyl-L-glutamate NCA (BLG NCA) in the presence of aniline, ethylenediamine, and triethylaminetriamine, respectively, while the cyclic-TNAPs are prepared in the absence of amine initiators. The tailored ANAPs possess superior antimicrobial activity against Gram-positive and Gram-negative bacteria. |
