| 초록 |
Conventional methods of controlling cell activity are being attempted by functionalized cell culture scaffold based on physicochemical clues. Above all, the modification of cell membrane with biomaterials recently has been growing as novel approach to regulate stem cell fate comparing with previously reported technic, in which topographical, chemical, physical factor used. In this study, we modified the stem cell membrane with multilayered polymeric nanofilms to promote thereof differentiation into specific cell lineage and cell protection effect under harsh condition. We designed functional nanofilm on mesenchymal stem cell (MSC) and multilayer films promote chondrogenesis and increase cell survival in blood vessel for 3 days and increased homing effect of MSCs to injured area. In this report, we concluded that the film could enhance cell functions such as viability, stability and differentiation and this approach could provide tool for increase the efficacy of MSCs for cell therapy. |
