| 초록 |
Self-assembled hyaluronic acid nanoparticles are considered to be promising drug carriers for cancer therapy because of their binding ability to CD44, a receptor over-expressed on many cancer cells. However, a major drawback preventing HA-based drug carriers in realizing the efficient therapy lies in an inability to overcome the preferential accumulation at the liver site. In an attempt to overcome these problems, we have prepared PEGylated, mineralized hyaluronic acid nanoparticles (P-MHANPs) under ambient conditions. These nanoparticles showed enhanced drug release under acidic environment, owing to dissolution of calcium phosphate minerals under mild acidic conditions. Overall, these mineralized nanoparticles might be useful as the carriers for the anticancer drugs and imaging agents. |
