| 초록 |
The design of functional scaffolds for tissue repair and regeneration requires gaining precise control of surface properties. Here, we propose a new methodology to fabricate multiscale nanotopographic scaffolds with controlled hydrophilicity via capillary force lithography in combination with plasma treatment. Using our method, we developed biodegradable polycaprolactone-based multiscale nanotopographic scaffolds with extracellular matrix-like structures along with controlled hydrophilicity by treating nitrogen and oxygen plasma. In response to multiscale nanotopography and chemically modified surface, the proliferation and osteogenic mineralization of cells were significantly promoted. Furthermore, the multiscale nanotopographic scaffolds enhanced regeneration of the rotator cuff tendon tissue and the calvarial bone tissue. Overall, the multiscale nanotopographic scaffolds could accelerate soft and hard tissue regeneration. |
