| 초록 |
Currently, All of the infants have to be prescribed by three consecutive injection of hepatitis vaccine just after his born. This intramuscular injection accompanies patient's pain and is uncomfortable, and more serious to newborn baby. In this study, chitosan nanoparticles were synthesized by ionic cross-linking gelation and then attached with hepatitis type B virus surface antigen(Hbs-Ag) for the vaccination. its approximately range was from 100nm to 150nm, and surface charge density was +60mV. The drug transport efficiency through the thigh muscle and nasal cavity was demonstrated in vivo test of SD rats. Characteristics of nanoparticles were examined by ELS, UV-visible Spectrometer, TEM, FT-IR. |
