| 학회 | 한국공업화학회 |
| 학술대회 | 2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 26권 1호 |
| 발표분야 | 포스터-생체재료 |
| 제목 | Viral protein contained photoreactable polymeric nanoparticle for nasal administrate vaccination and immune boosting |
| 초록 | We need to prevent virusinfection. As one tool to prevent virus infection is vaccine. Vaccines deliverantigens to antigen presenting cells. so that they have immunity to theantigens. Nasal vaccine is being studied. But nasal vaccine has disadvantagethat easily removable through mucosa and clearance in nasal. So, wedeveloped photoreactable positive charged polymer (PPP). PPP as photosensitizerconjugated polymer can generate reactive oxygen species (ROS). ROS enhancepenetration of antigen through mucosal barrier disruption. PPP can formnanoparticle with negative charged viral protein. It is photoreactable virusvaccine (PVV). We confirmed ROS generation ability of PVV and long timesretention in nasal cavities using FITC labeled PVV. We confirmed immune cells andantigen specific secretary IgA and IgG titer upregulated through vaccination. WhenPVV was infected with the virus after intranasal administration, the weightloss was reduced and the survival rate was increased. |
| 저자 | 이장수1, 정하윤1, 이충성2, 이종환1, 황희숙3, 이민4, 나건1 |
| 소속 | 1가톨릭대, 2선문대, 3단국대, 4Univ. of California Los Angeles |
| 키워드 | Nasal vaccine; Photosensitizer; Polymeric Nanoparticle. Antigen |
