| 초록 |
In this study, we synthesized near-infrared (NIR) fluorescent nanocarriers with conjugating various mannose moieties on the surface to target macrophages in the lymph node. Armed with these NIR nanocarriers, we demonstrated the feasibility of intraoperative pan lymph nodes (PLN) mapping and real-time optical imaging under the NIR fluorescence imaging system. We found that even single mannose-conjugated ZW800-1 showed specific uptake in lymph nodes within 4 h, and multiple mannose-employed polyrotaxanes highlighted PLN efficiently with low background signals in major organs. This technology can help surgeons perform lymphadenectomy with ease and safety by identifying all regional lymph nodes proficiently after a single intravenous injection of NIR nanocarriers. |
