| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 봄 (05/02 ~ 05/04, 대구 엑스코(EXCO)) |
| 권호 |
22권 1호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Polymeric Scaffolds of Fibroblast-derived Extracellular Matrix and PLGA composites for Renal Tissue Regeneration |
| 초록 |
Bio-mimetic scaffolds for repairing an injured tissue are emerging as a promising approach in the field of kidney tissue engineering. In this work, we developed extracellular matrix (ECM) incorporated PLGA (PLGA/ECM) 3D bio-mimetic porous scaffolds as a cell supporting material for kidney tissue regeneration. PLGA/ECM scaffolds were prepared and characterized through various analyses. Cell proliferation on the scaffolds increased with increases in ECM concentrations. The PLGA/ECM scaffold was shown to be an effective matrix for the reconstitution of glomerulus in partially nephrectomized mice, compared with only PLGA control. These results suggest that the ECM incorporated PLGA 3D porous scaffolds could be one of the promising materials for tissue regeneration including kidney. |
| 저자 |
김윤아1, 전소영2, 유승권3, 권태균2, 한동근4, 정윤기1
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| 소속 |
1한국과학기술(연), 2경북대, 3고려대, 4차의과대 |
| 키워드 |
renal tissue regeneration; porous scaffold; fibroblast extracellular matrix; nephron progenitor cells
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| E-Mail |
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