| 초록 |
The causes of nerve injury have been referred to traffic accidents, tumor damages, viral infections and the side effects of neurosurgery. Their sufficient functional recovery is considered as one of the common clinical problems. In our previous study, we observed that the asymmetrically porous PLGA/Pluronic F127 nerve guide conduit (NGC) developed by our laboratory can provide good environment for nerve regeneration. In this study, we applied ultrasound at the PLGA/F127 NGC-implanted site transcutaneously for more enhanced nerve regeneration. The PLGA/F127 NGC-implanted animals (sciatic nerve defect of rats; defect size, 10 mm) were received ultrasound at a frequency of 1 MHz and intensity 0.4 W/cm2 for 2 min with different stimulation patterns. Their nerve regeneration behaviors were compared with the control (PLGA/F127 NGC without ultrasound) and normal nerve by histological observations (Toluidine blue staining and TEM). |
