| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 가을 (10/31 ~ 11/02, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
22권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Robust immobilization of neuronal cell membrane on neural interfacing devices for competent tissue integration |
| 초록 |
At the interface of an neural probe, immune responses limit the recording stability of the device. To prevent this negative actions, we fabricated titanium substrates covered with cell membranes extracted from differentiated PC12 cells to induce the surface localization of neuronal adhesion molecules, which promotes neurite outgrowth and neural network formation. The modified substrate was prepared by pre-tethering of lipids on the surface and introducing extracted membrane components by vesicle fusion method. The surface modification was investigated by FT-IR, confocal microscopy and FRAP assay. Further, in vitro cell study revealed encouraging results in terms of adhesion and differentiation of neuron, showing different behavior of astrocyte from those of neuron was also observed. In conclusion, our study demonstrates that this system would act as an efficient tool for modulating immune response of neural probes. |
| 저자 |
김가을1, Mahmoud amr Elnaggar1, Hyun Cheol Kim2, 정윤기1
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| 소속 |
1한국과학기술(연), 2서강대 |
| 키워드 |
neural interface; TLB; cell adhesion molecule; Neurite outgrowth
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| E-Mail |
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