| 초록 |
Developing biomaterials capable of changing their characteristics such as particle distribution and inherent structure can help unravel the interactions between the cells and material surface. In this session, reversibly controllable magnetic nano-systems in macro and nanoscale are demonstrated. Our research group designed ligand-presenting magnetic nanoparticles, which are electrostatically attached to on the surface, to allow macroscale ligand movement depending on the direction of the magnet. Also, we developed magnetically controllable unique nanohelices that are partially coupled to the surface. Magnetically induced winding and unwinding structure which lead to ligand-gap regulated macrophage adhesion. By these nano-systems, our research group demonstrated the regulation of cell adhesion toward regenerative M2 polarization both in vitro and in vivo. Our novel technique of manipulating implanted systems can give insight to remote regulation of functional characteristics of cells. |
