| 학회 |
한국공업화학회 |
| 학술대회 |
2017년 봄 (05/10 ~ 05/12, 광주 김대중컨벤센센터(Kimdaejung Convention Center)) |
| 권호 |
21권 1호 |
| 발표분야 |
생체재료 |
| 제목 |
Highly soluble nanocomplex of PEG and polyphenol for dry eye diseases |
| 초록 |
Flavonoid is polyphenolic molecule from fruit and plant. Catechin is one of the flavonoid that exists in green tea. Flavonoids are generally known for their advantageous properties such as anti-inflammation, anti-oxidant, and anti-cancer. Many flavonoids are poorly soluble in water which is a serious drawback to be used in bio-applications. In this study, we increased aqueous solubility of catechin through complexation with poly(ethylene glycol) (PEG). The experimental procedure does not consist a covalent conjugation. Also, the complexation does not require chemical cross-linker or initiator. The preparation is simple but the solubility enhancement is high (at least 50 mg/ml). In this study, highly soluble nanocomlex of catechin is used in in-vivo to treat dry eye diseases. The nanocomplex showed anti-inflammation property and increased goblet cell density which helps dry eye diseases. The optimal weight ratio of complex was PEG-catechin 10 for dry eye model. |
| 저자 |
심휘수1, Hye Sook Lee2, Jae Wook Yang3, 이해신2
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| 소속 |
1KAIST, 2Ocular Neovascular Disease Research Center, 3Inje Univ. Busan Paik Hospital |
| 키워드 |
ocular drug; polyphenol; anti-angiogenesis
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| E-Mail |
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