| 학회 |
한국재료학회 |
| 학술대회 |
2019년 가을 (10/30 ~ 11/01, 삼척 쏠비치 호텔&리조트) |
| 권호 |
25권 2호 |
| 발표분야 |
B. 나노화학/바이오 재료 분과 |
| 제목 |
Biphasic Calcium Phosphate (BCP) Porous Scaffolds Loaded with Soya-Gelatin Hydrogel for improved mechanical property and osteoconductivity |
| 초록 |
Bone fractures are treated with bioceramic based materials such as biphasic calcium phosphate (BCP) scaffolds. BCP is an attractive choice as bone substitute for not only possessing similar mineral composition to bone but also having excellent biocompatibility, degradability, and osteoconductive property. Herein, porous BCP scaffolds were loaded with foamed soya-gelatin hydrogel to improve strength of the scaffold whereas hydrogel was optimized by 10% soya with 5% gelatin. In addition, soya is known for its osteogenic and macrophage modulating property. The pore size of the BCP scaffold ranged from 200-300 µm while soya-gelatin hydrogel loaded BCP scaffold micropore size ranged from 10-40 µm and macropore size ranged from 200-300 µm. The compressive strength of the BCP scaffold, and BCP/soya-gelatin scaffolds were 0.326 ± 0.03 MPa, 0.82 ± 0.029 MPa, and 2.711 ± 0.065 MPa respectively. As a whole, the protein foamed scaffold would have sufficient mechanical strength, and would possess both osteoconductive and osteoinductive properties, which are essential considerations for bone substitutes. |
| 저자 |
Byong Taek Lee1, Mosharraf Hossain2, Soo-Bin Im3, Celine Abueva4, Omar Faruq5
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| 소속 |
1Department of Regenerative Medicine, 2Institute of Tissue Regeneration, 3College of Medicine, 4Soonchunhyang Univ., 5South Korea |
| 키워드 |
Bone substitute; scaffold; biphasic calcium phosphate; osteoconduction; osteoinduction
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| E-Mail |
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