| 초록 |
Oxazolidinone, a new class of synthetic antibacterial agents, have shown biological activity against multidrug-resistant gram positive organisms. Several synthesis and biological activity of novel oxazolidinones have been reported and the first oxazolidinone derivative, linezolid (Zyvox™) is now being marketed for the treatment of multi-drug resistant Gram-positive infections. In the course of our studies directed towards the discovery of novel antibacterial agents, which are expected to have improved drug efficacy and better toxicity profile than Linezolid, we have synthesized new derivatives of oxazolidinone mono and bisphosphonates prepared efficiently from commercially available L-serine and L-threonine. |
