| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 봄 (04/11 ~ 04/12, 대전컨벤션센터) |
| 권호 |
38권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
pH/temperature sensitive multiblock copolymer hydrogels from Poly(urethane sulfide sulfamethazine) used for DOX delivery in tumour-site |
| 초록 |
For the purpose of using polymeric hydrogel as drug/protein delivery system in mildly acidic environment of tumor-site, a series of novel multiblock copolymer was developed. These polymers were constructed of temperature-sensitive triblock poly(e-caprolactone-co-lactide) – poly(ethylene glycol) – poly(e-caprolactone-co-lactide) (PCLA-PEG-PCLA) and anionic pH-sensitive moiety poly(urethane sulfide sulfamethazine). With the decreasing of environment’s pH, these polymers can change rapidly from sol state into gel state with the gel window covered physiological and even midly acidic condition. This pH/temperature-sensitivity of these materials was shown in sol-gel transition diagrams and can be controlled by the change in their structures. Their gelation and degradation were also checked in vitro and in vivo. The sustained releasing of DOX in vitro was examined for the aim of cancer treatment therapy. |
| 저자 |
NGUYEN QUANG VINH1, 이두성2, HUYNHCONGTRUC3, 임재승4
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| 소속 |
1성균관대, 2Theranostic Macromolecules Research Center, 3Department of Polymer Science and Engineering, 4Sungkyunkwan Univ. |
| 키워드 |
pH/temperature sensitive; hydrogels; polyurethane; DOX release; tumour-site
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| E-Mail |
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