| 초록 |
An acidic tumor pH-responsive nanoparticle for targeted cancer therapy was demonstrated herein. The smart nanoparticle was prepared by self-assembly of a pH-responsive polymers having pH-cleavable linker. Since the hydrophilic polymer can be detached from the nanoparticles by hydrolysis of the pH-cleavable group at the pH of an acidic tumor ~6.5, the particle size and surface charge of the nanoparticle were changed along with the environmental pH condition. After detachment of the polymer, the nanoparticles became positively charged due to exposure of primary amine groups. From in vitro cellular experiments with cancer cells, the nanoparticle exhibited enhanced cellular internalization at acidic tumor pH compared to normal pH, which led to a significant cancer cell killing effect. These results suggest that this system has the potential to be used as a new class of smart nanoparticle for targeted cancer therapy. |
