| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Self-assembled Nanocapsules Based on A Stimuli-Sensitive Pentablock Copolymer for Gene Delivery |
| 초록 |
Amphiphilic block copolymers can self-associate to form characteristic ordered structures, such as a micelle-like core-shell structure, in an aqueous solution. A new pentablock copolymer having pH/temperature sensitive units was synthesized. The pentablock copolymer (PAE-PCL-PEG-PCL-PAE) consists of a temperature-sensitive triblock copolymer of poly(ethleneglycol)-poly(ε-caprolactone) (PCL-PEG-PCL) and pH-sensitive poly(β-aminoester) (PAE) blocks at both ends of the triblock copolymer. In this study, the pentablock copolymer was used as a new class of non-toxic, biodegradable carrier for gene delivery by forming nanocapsules entrapping nucleic acid drug. |
| 저자 |
허진희1, 오태환1, Cong Truc Huynh1, 최지숙2, 유혁상2, 이두성1, 정지훈1
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| 소속 |
1성균관대, 2강원대 |
| 키워드 |
thermosensitive; pH-sensitive; block-copolymer; gene delivery
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| E-Mail |
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