| 초록 |
In this study, an efficient process of negative pressure cavitation based ultrasound-assisted fractional precipitation was invented, and applied for the purification of paclitaxel from biomass of Taxus chinensis for the first time. The precipitation efficiency of paclitaxel from Taxus chinensis was remarkably improved through ultrasound-negative pressure cavitation fractional precipitation. As a result of investigating the mechanism of fractional precipitation in which ultrasonic cavitation and negative pressure cavitation bubbles were introduced, it was found that bubbles themselves acted as sites for nucleation (acting like foreign particles). In addition, the ultrasound-negative pressure cavitation precipitation behavior was quantitatively investigated by calculating the precipitate size and diffusion coefficient of paclitaxel. [This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Government of Korea (MSIT) (Grant Number: 2021R1A2C1003186).] |
