| 초록 |
Over the last couple of decades, recognition of diverse hormones in the human body is a highly significant challenge because serious diseases, such as osteoporosis, adenoma, cardiovascular, hyperplasia, and cancer, can be affected by hormonal imbalances. Herein, we report an approach to facilitate formation of close-packed arrays of carboxylated polypyrrole nanoparticles (CPPyNPs) with human parathyroid hormone receptor (hPTHR) for liquid-ion-gated field-effect transistor (FET)-type hormone sensor. Field-induced signals provided highly sensitive and selective recognition of target molecules at unprecedentedly low concentrations (ca. 48 fM). This hormone sensor also showed long-term stability and excellent selectivity in fetal bovine serum. Moreover, synergistic effects corresponding to increased hPTH peptide length were monitored. |
