| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 봄 (04/07 ~ 04/09, 대전컨벤션센터) |
| 권호 |
46권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 Ⅰ |
| 제목 |
Novel blue light source triggered angiogenic photobiomodulation in stem cells for hindlimb ischemia treatment |
| 초록 |
Conventional blue light source such as light emitting diode has been rarely used in light therapy due to their high energy. High energy of blue light normally induces excessive reactive oxygen species (ROS) generation in cells inducing phototoxicity. Blue organic light emitting diode (bOLED) in this study has low luminance and heat generative property that rarely causes cellular damage. We have optimized blue light condition in terms of wavelength and light dose. Optimized bOLED light did not induce phototoxicity but induce mild ROS generation in human adipose derived stem cells (hADSCs). Mild ROS generation induced redox signaling to increase biomodulation and angiogenesis. Transplantation of bOLED-pretreated hADSCs also stimulated tissue regeneration in mouse hindlimb ischemia model. |
| 저자 |
현지유, 방석호
|
| 소속 |
성균관대 |
| 키워드 |
OLED; photobiomodulation; stem cell; ischemia disease
|
| E-Mail |
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