| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 봄 (05/01 ~ 05/03, 부산 벡스코(BEXCO)) |
| 권호 |
23권 1호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Nature-inspired nanoparticles coated with glycosaminoglycan-photosensitizer for cancer specific therapy |
| 초록 |
To treat cancer more effectively, combination therapy has been studied with photodynamic therapy(PDT). We designed nature-inspired polymer nanoparticles which have biocompatibility and photothermal effect under NIR condition. These nanoparticles coated with glycosaminoglycan that is also biocompatible natural polymer and able to target cancerous cells. Photosensitizer(PS), a powerful reactive oxygen species(ROS) generator, is conjugated with glycosaminoglycan so that photodynamic effect can be controllable. Cancer specific therapy is an important issue in PDT, because of unwanted side-effects. Our nanoparticles(NGPs) have high water solubility, cancer selective internalization, controlled toxicity under laser irradiation condition and enhanced anticancer activity with photothermal effect. We suggest that NGPs are a promising combination cancer therapy agent. |
| 저자 |
이창주1, 한지은1, 박신정1, 나건1, 박우람2
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| 소속 |
1가톨릭대, 2차의과대 |
| 키워드 |
photodynamic therapy; combination therapy; targeting cancer
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| E-Mail |
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