| 초록 |
Upconversion nanoparticles (UCNP) represent as a promising agent in biomedical applications. However, intrinsically low quantum efficiency have restricted their viable applications. The incorporation of localized surface plasmon resonance (LSPR) has been considered as a promising pathway to overcome this limitation. Herein, we first time to develop the Au NR@TiO2 decorated with UCNP to utilize the phototherapy by plasmon-enhanced upconversion luminescence. TiO2 shell not only used for spacer between plasmonic nanostructures and UCNP to prevent quenching effect, but also directly used as inorganic photosensitizer. In the presence of UCNP, the emitted UV light excited the TiO2 and generated the cytotoxic reactive oxygen species. In addition, emitted visible light was re-absorbed by plasmonic nanostructures to further enhance photocatalytic activities due to the generated hot electrons. Furthermore, LSPR-induced photo-thermal effect was utilized for achieving the photothermal therapy.
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