| 초록 |
Recently, the use of plasmonic metal nanostructures such as gold nanoparticles (AuNP) for phototherapy has gained considerable attention as a powerful non-invasive technique for various cancer treatments. In this study, we developed a gold nanorod (AuNR)-based system for synergistic photodynamic therapy (PDT) and photothermal therapy (PTT). A series of AuNRs with different aspect ratio were synthesized by seeded growth method. Then, FA-conjugated block copolymers were employed to modify AuNRs and photosensitizers were covalently incorporated into the AuNRs conjugates through the glutathione-sensitive linkages. The physicochemical properties of the multifunctional AuNRs-based system were evaluated. In addition, the cellular uptake and phototoxicity test were conducted using MCF 7 and A549 cell lines in vitro. |
