| 초록 |
Micelle-like aggregates or nanoparticles formed with amphiphilic block or graft copolymers have been recently studied for a possible application of drug carriers. In the present study, novel amphiphilic graft copolymers composed of poly(amino acids) derivatives as the hydrophilic backbone and oligo(L-leucine) or oligo(L-valine) as the grafted hydrophobic chain were successfully synthesized by a ring-opening polymerization of the Leu-NCA (val-NCA) to backbone polymer. The amphiphilic graft copolymer formed nano-size self-assemblies with unique morphology in aqueous solution. The hydrophobic domains can adopt regular conformations that are insoluble in water, namely, rod-like -helices for oligo(L-leucine) and crystalline β-sheets for oligo(L-valine). The unique self-assemblies in aqueous solution were observed with DLS, fluorescence, CD, TEM, and SANS. |
