| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
의료용 고분자 부문위원회(초청-영어발표/포스터-국문발표 가능) |
| 제목 |
Synthesis of Poly(ethylene glycol)/ poly(trimethylene carbonate) AB2 Miktoarm Copolymers for Anticancer Drug Delivery |
| 초록 |
Amphiphilic AB2 miktoarm copolymers that mimic structural characteristics of phospholipid show a great potential for drug delivery applications. In this study, a series of amphiphilic AB2 miktoarm copolymers consisting of hydrophilic poly(ethylene glycol) (PEG) as A block and hydrophobic poly(trimethylene carbonate) (PTMC) as B block were synthesized by ring-opening polymerization of TMC using methoxy PEG as a macroinitiator. The chemical compositions of PEG-PTMC2 miktoarm copolymers were confirmed by 1H-NMR, GPC, and FT-IR measurements. The miktoarm copolymers, PEG2k-PTMC2k and PEG2k-PTMC4k, readily formed spherical micelles (40~50 nm) when they self-assembled in aqueous solution. Paclitaxel (PTX) was efficiently loaded into PEG-PTMC2 micelles. The drug loading capacity and release characteristics of the miktoarm copolymer micelles were evaluated in comparison with comparable diblock copolymer micelles. |
| 저자 |
서진솔1, 이립1, 이나은1, 이은지1, 배유한2, 허강무1
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| 소속 |
1충남대, 2유타대 |
| 키워드 |
Miktoarm copolymer; Self-assembly; Drug delivery
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| E-Mail |
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