| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 봄 (04/10 ~ 04/12, 부산컨벤션센터(BEXCO)) |
| 권호 |
44권 1호 |
| 발표분야 |
고분자합성 |
| 제목 |
Dox and IR-780 Dye-Encapsulated Nano Micelles Based on Linear Cyclic Polymer for Enhanced Tumor therapy |
| 초록 |
We prepared a series of triblock poly(N-isopropylacrylamide)30-block-cyclic poly(L-lysine)n-block- poly(N-isopropylacrylamide)30 (p(NIPAM)30-b-Cyclic p(L-LYS)n- p(NIPAM)30) (n=10,20 and 30) polymer bio-conjugates via combination of reversible addition fragmentation chain transfer, Click reaction and ring opening polymerization of α-amino acid N-carboxyanhydrides. All the triblock polymer forms spherical micelles in aqueous solution and micelles were stabilized using terephthalaldehyde cross-linker with successfully encapsulating Doxorubicin (Dox) and IR-780 dye. Moreover, polymer micelles exhibited excellent drug loading capacity and drug loading efficiency, also in vitro drug release profile demonstrated that the maximum release of Dox was happened in pH 5.0 at 42 oC and in presence of glutathione intracellular mimic environment. The results of linear-cyclic polymer system expecting to be nice for the further studies in anticancer therapy. |
| 저자 |
RIMESH AUGUSTINE1, 김일1, Saji Uthaman2, 박인규2
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| 소속 |
1부산대, 2전남대 |
| 키워드 |
photothermal therapy; biopolymers; IR-780; block copolymers.
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| E-Mail |
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