| 학회 |
한국고분자학회 |
| 학술대회 |
2020년 가을 (10/05 ~ 10/08, 부산컨벤션센터(BEXCO)) |
| 권호 |
45권 1호 |
| 발표분야 |
고분자합성 |
| 제목 |
Self-Assembly of Two-Tailed Tadpole-Shaped Amphiphilic Copolypeptides |
| 초록 |
Smart amphiphilic polypeptide self-assembly derived nanoparticles offer unique control over molecular behavior for biomedical engineering applications. In this work we have synthesized a two-tailed tadpole-shaped poly(N-isopropylacrylamide)20-block-(cyclic-poly(L-lysine)25)-block-poly(N-isopropylacrylamide)20 amphiphilic copolymer utilizing reversible addition-fragmentation chain transfer polymerization (RAFT), click cyclo addition reaction and ring-opening polymerization of α-amino acid N-carboxyanhydrides. The polymer was characterized using 1H nuclear magnetic resonance and Fourier-transform infrared spectroscopy. Final amphiphilic copolymers were self-assembled into spherical micelles, two-dimensional square, cubic, rods and thread-like fiber morphologies under various self-assembly conditions and confirmed using transmission electron microscopy. The selfassemblies were controlled by the factors such as type of solvent ratio of of the solvents and polymer concentration. |
| 저자 |
전수현, 김일, Rimesh Augustine, Nagendra Kalva
|
| 소속 |
부산대 |
| 키워드 |
N-isopropylacrylamide; polypeptide; self-assembly; nanoparticles
|
| E-Mail |
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