| 학회 |
한국화학공학회 |
| 학술대회 |
2021년 봄 (04/21 ~ 04/23, 부산 BEXCO) |
| 권호 |
27권 1호, p.468 |
| 발표분야 |
생물화공 |
| 제목 |
Encapsulation of superparamagnetic iron oxide nanoparticles with polyaspartamide biopolymer for hyperthermia therapy |
| 초록 |
We report a delicate synthesis process of polyaspartamide-encapsulated superparamagnetic iron oxide nanoparticles (PA-SPIONs) with their sufficiently obtained grain-size below 100 nm for hyperthermia application. Iron oxide nanoparticles with a high magnetization have been applied as nano-heaters while PA is a biocompatible and biodegradable polymer with a polysuccinimide (PSI) backbone. Multi-functional polymer PA could be conjugated with other groups such as biotin to enhance the uptake capability by receptors of cancer cells. Consequently, encapsulating SPIONs nano-heaters with PA biopolymer is an attractive roadmap for hyperthermia therapy application. Our results revealed that PA-SPIONs showed excellent biocompatible behavior based on cell viability test. With Prussian blue staining of cancer cells (4T1), cellular uptake of PA-SPIONs was significantly increased in the presence of biotin conjugated on the outer shell. Furthermore, PA-SPIONs exhibited effective cancer killing activities in both in vitro and in vivo hyperthermia experiments. |
| 저자 |
Nguyen Minh Phuong1, 김덕준2
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| 소속 |
1Sungkyunkwan Univ., 2성균관대 |
| 키워드 |
생물화학공학 |
| E-Mail |
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| 원문파일 |
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