| 초록 |
Nanoparticles with bone targeting ability and pH-sensitivity were prepared with polyaspartamide derivatives based on polysuccinimide grafted with octadecylamine, hydrazine and polyethylene glycol For the bone targeting, alendronate, which has bone affinity, was grafted to PEG and doxorubicin was conjugated with linkers of acid sensitive hydrazone bonds, which can be cleaved most effectively in an intracellular acidic environment. At pH 5.0, ∼75% of the drug was released from ALN-PEG/C18/HYD-DOX-g-PASPAM due to the effective cleavage of HYD under the acidic condition. Also, ALN-bound particles were more effectively adsorbed on the surface of bone than ALN-unbound particles. According to an in vivo antitumor activity test, the volume of tumor treated with ALN-PEG/C18/HYD-DOX-g-PASPAM decreased (1550mm3) when compared with the PBS control sample (3850mm3), proving that ALN-PEG/C18/HYD-DOX-g-PASPAM is an effective drug delivery system for the treatment of bone metastasis of breast cancer. |
