| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 가을 (10/06 ~ 10/08, 대구컨벤션센터(EXCO)) |
| 권호 |
40권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Self-Assembled Nano Aggregates Based on Polyaspartamide Graft Copolymers for pH-Controlled Release of Doxorubicin |
| 초록 |
A series of biodegrabable graft copolymer polyaspartamide derivatives were synthesized by grafting of O-(2-aminoethyl)-O'-methylpoly(ethylene glycol) 5000 (MPEG) on polysuccinimide(PSI), and conjugeted doxorubicin with linkers of acidsensitive hydrazone bond. This hydrazone bonds can be cleaved most effectively in an intracellular acidic environment. and conjugeted cholic acid as hydrophobic moieties. The chemical structure of the polymer and the degree of substitution of the prepared polymer was confirmed using FT-IR and 1H NMR spectroscopy. Their pH-sensitive properties were characterized by light transmittance measurements, and the mean particle size and their distribution were investigated by dynamic light scattering measurement through varying pH values. And this polymeric micelle can be a potential carrier for the drug delivery system. |
| 저자 |
김덕준, 임철원
|
| 소속 |
성균관대 |
| 키워드 |
hydrazone bond; micelle; doxorubicin
|
| E-Mail |
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