| 학회 |
한국공업화학회 |
| 학술대회 |
2007년 가을 (11/02 ~ 11/03, 한경대학교) |
| 권호 |
11권 2호 |
| 발표분야 |
고분자 |
| 제목 |
Application of low molecular weight water soluble chitosan nanoparticle modified with folate for efficient gene delivery |
| 초록 |
Gene therapy using LMWSC (low molecular water soluble chitosan) as polycationic polymer shows good biocompatibility, but low transfection efficiency. The mechanism of folic acid (FA) uptake in the cells to promote targeting and internalization could improve transfection rates. The objective of this study was to synthesize and characterize WSCFA-DNA complex and evaluate their cytotoxicity in vitro. WSCFA nanoparticles have less cytotoxicity, good DNA condensation and particle size around 110nm, which makes them a promising candidate as a non-viral gene vector. |
| 저자 |
허선행, 장민자, 김동곤, 정영일, 장미경, 나재운
|
| 소속 |
순천대 |
| 키워드 |
LMWSC; Folic acid; Nanoparticle; Gene therapy
|
| E-Mail |
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