| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
23권 2호 |
| 발표분야 |
포스터_생체재료 |
| 제목 |
Polydioxanone(PDO) dermal filler and its collagen regenerating effect in skin layer |
| 초록 |
As rapid growth of interest in beauty, market of cosmetic dermal filler is emerging in the world. Since the first cross-linked hyaluronic acid (HA) dermal filler was approved in FDA, it occupied major part of this market up to this day. However, the HA filler has a limit because of its toxicity due to 1,4-Butanediol diglycidyl ether (BDDE) cross linker. So, the FDA strictly regulated the amount of BDDE usage. This concern leads to interest in biodegradable polymer as the dermal filler. We processed biodegradable PDO micro particle and confirmed its effect as dermal filler application. In order to confirm the in-vivo volume enhancing effect of the PDO filler, it was injected into back skin layer of mouse, and its retention time of enhanced volume was detected. Furthermore, we confirmed collagen regeneration around the injected PDO particle in skin layer. Our PDO filler is currently ongoing clinical trial to confirm its safety and is expected to be approved in KFDA next year. |
| 저자 |
이청천, Lia Priscilla, 곽민석, 전효선, 심용호, 권한진
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| 소속 |
(주)울트라브이 |
| 키워드 |
Polydioxanone; dermal filler; biodegradable polymer
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| E-Mail |
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