| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 가을 (10/20 ~ 10/22, 경주컨벤션센터) |
| 권호 |
46권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 Ⅰ,Ⅱ |
| 제목 |
Systematic studies of biodegradable PLLA-PDO core-sheath monofilamentous stents for nonvascular implantation |
| 초록 |
Polydioxanone (PDO) has been widely used in bio-medical fields for its high flexibility and biocompatibility. However, PDO stent carries several drawbacks such as its low mechanical stability during degradation. In this study, we designed the PLLA-PDO core-sheath monofilament based stents for the optimized mechanical properties, biodegradability, and drug release. Decreases in tensile strength, elastic modulus, and elongation properties were delayed in the PLLA-PDO monofilament compared to the PDO monofilament during degradation. In addition, we loaded dexamethasone in the PLLA-PDO monofilament. Dexamethasone-loaded PLLA-PDO monofilament showed no difference in the degradation behavior compared to the drug unloaded PLLA-PDO monofilament. Furthermore, we confirmed the sustained release of dexamethasone from PLLA-PDO monofilaments. Overall, our drug-eluting sheath-core monofilament stents can be a promising model for advanced nonvascular implantation. |
| 저자 |
양승원1, 정윤기1, Cheol-Min Han2, Eugene Lih3, Seul-Ki Choia4, 한동근, 손준식3
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| 소속 |
1한국과학기술(연), 2Department of Carbon and Nano Materials Engineering, 3Department of Biomedical Engineering, 4Korea Univ. of Science and Technology |
| 키워드 |
core-sheath monofilament; drug-eluting stent; polydioxanone; poly (L-lactic acid)
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| E-Mail |
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