| 초록 |
In these days, a sort of cancer remedy is photodynamic therapy (PDT) and it is widely used in clinical. Whereas, conventional photodynamic materials, photosensitizer (PS) showed high off-target side effect and photoactivation. To overcome drawbacks, we manufactured cancer-specific and photoactivity-controllable nanomedicine which is coated with cancer targeting polysaccharide-PS (PP) on polydopamine nanoparticle (PD-NP). Under cancer mimicking condition, the PP-NPs exhibited high singlet oxygen generation efficacy. Also, efficient photothermal conversion for photothermal therapy (PTT) was confirmed. In mouse tumor model, the photo-triggered PDT/PTT effect of the PP-NPs was much higher in cancer microenvironments than normal tissue. Consequently, the PP-NPs showed antitumor efficacy in mouse model and for efficient cancer treatment, nanoparticle photomedicine would be innovative strategy. |
