| 초록 |
Stable blood compatibility of polymeric membranes used in contact with human whole blood is highly desirable for blood-inert devices. The development of nonfouling polymers is therefore critically important in biomedical applications, which are important in the design for human blood-contacting materials. However only a very limited number of synthetic biomaterials are regarded as good hemocompatible candidates. It is suggested that a nanoscale homogenous mixture of balanced charge groups from polyzwitterionic materials is the key to controlling nonfouling properties. An important characteristic of a zwitterionic structure is that it should have both a positively and a negatively charged moiety within the same side chain segment while maintaining overall charge neutrality. A set of functional properties is generally used to guide the design of new non- fouling polymer brushes in contact with human blood: they should be hydrophilic and electrically neutral, and hydrogen bond acceptors rather than hydrogen bond donors. For the polyzwitterionic materials, they can be further classified into polybetaines such as 2-methacryloyloxylethyl phosphorylcholine (MPC), sulfobetaine methacrylate (SBMA), and carboxybetaine methacrylate (CBMA). The advantages of nonfouling zwitterionic materials include the simplicity of synthesis, ease of applicability, abundance of raw materials, and availability of functional groups. Our laboratory mainly focuses on the study of zwitterionic SBMA polyemrs for their fundamental molecular designs as well as the development for practical biomedical applications. |
