| 학회 | 한국공업화학회 |
| 학술대회 | 2021년 가을 (11/03 ~ 11/05, 대구 엑스코(EXCO)) |
| 권호 | 25권 2호 |
| 발표분야 | 포스터-생체재료 |
| 제목 | Polysaccharide-Polymer Nanoparticle for Inhibition of Doxorubicin cardiotoxicity |
| 초록 | Doxorubicin (DOX) is an anti-cancer agent used for various cancers. However, the concentration-dependent cardiotoxicity occurs from doxorubicinol (DOXol), which is formed from the metabolism of DOX. In this study, we present novel polysaccharide-polymer nanoparticles (PPNPs) to control the release rate of DOX for inhibition of producing DOXol. Also, we selected a tumor overexpressed-receptor specific polysaccharide (RSP) to improve cellular uptake. PPNPs demonstrated improved cellular uptake, which was confirmed by competitive inhibition of free RSP. To evaluate the efficiency of PPNPs, we confirmed the pharmacokinetics of PPNPs by plasma, tissue concentration of DOX/DOXol. These data demonstrated that metabolism of DOX significantly decreased compared by free DOX, which result in reduced cardiotoxicity. As a result, effective treatment can be expected to reduce cardiotoxicity by delivering specifically to cancer through PPNPs and successfully inhibiting the formation of DOXol. |
| 저자 | 노재원, 조영엄, 이채빈, 배수경, 나건 |
| 소속 | 가톨릭대 |
| 키워드 | cancer treatment; chemotherapy; nanoparticle |
