| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 가을 (10/20 ~ 10/22, 경주컨벤션센터) |
| 권호 |
46권 2호 |
| 발표분야 |
고분자합성 |
| 제목 |
Hyaluronic acid based hydrogel as injectable carrier of Human induced nephron cells for kidney regeneration |
| 초록 |
Hydrogels are considered as delivery stem cell carries for various medical applications because of their excellent water absorption and filling ability. Herein, we developed a hyaluronic acid/gelatin(CHO-HA/Gel-NH2) hydrogel for therapeutic kidney regeneration without any chemical crosslinking agents. Hydrogel were simple fabricated by mixing two polymer solutions. Hydrogel at ratio CHO-HA(10%)/Gel-NH2 (20%)=3/7 enhanced high swelling ratio, great mechanical property and slow degradation. Hydrogels were used to encapsulated Human induced nephron progenitor cells(iNPCs) to provide a microenvironment biocompatible with cell culture. iNPCs retained their proliferative capacity in the hydrogel and that the hydrogel could be used as a vehicle for the delivery of iNPCs. These results clearly indicated that the developed hydrogels have been excellent biocompatibility, which may be beneficial for kidney regeneration. |
| 저자 |
수리랏1, 박한수2
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| 소속 |
1Chung-Ang Univ., 2중앙대 |
| 키워드 |
Kidney regeneration; hydrogel; hyaluronic acid; tissue engineering; progenitor cells
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| E-Mail |
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