| 학회 |
한국재료학회 |
| 학술대회 |
2016년 가을 (11/16 ~ 11/18, 경주 현대호텔) |
| 권호 |
22권 2호 |
| 발표분야 |
B. 나노화학/바이오 재료 분과 |
| 제목 |
Surface Modification of Magnesium Based Alloys for Biomedical Applications |
| 초록 |
Magnesium (Mg) alloys due to their low weight, bone-like mechanical properties and being degradable in vivo are widely used as the promising bone enhancement biomaterial. However, magnesium is highly susceptible to corrosion in physiological conditions, which results in a decrease in its mechanical properties before the new tissue has healed. Surface modification of Mg alloys will improve the biocompatibility of these alloys by reducing the degradation rate and inducing better bone-implant interfaces. The present work addresses the studies on organic based coatings on biodegradable ZK60 magnesium alloy for bone regeneration. Bioactive duplex coatings comprises of Mg(OH)2/MgF2 conversion coatings as underlayer and polymer coatings as the outer layer. Polymer coatings were prepared using dip coating technique. The morphological, elemental, phase analysis, in vitro corrosion and cell viability studies were carried out for duplex coatings and compared with uncoated samples. The results revealed that ceramic conversion coating followed by polymeric coating combinations exhibited superior resistance to corrosion and improved biocompatibility than the uncoated and single conversion layer coated samples. Hydrogen evolution measurements and pH change over a two weeks indicated longer range corrosion protection in comparison to the uncoated substrates. The duplex coatings showed improved biocompatibility and cell proliferation with respect to uncoated ones utilizing pre-osteoblast MC3T3 cells. These organic based coatings on magnesium implants show huge potential for biomedical applications. |
| 저자 |
Preeti Makkar1, Jhaleh Amirian2, Byong-Taek Lee3
|
| 소속 |
1Institute of Tissue Regeneration, 2College of Medicine, 3Soonchunhyang Univ. |
| 키워드 |
Magnesium alloy; Polymer; Coatings; Corrosion; Biodegradable
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| E-Mail |
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