| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
의료용 고분자 부문위원회(초청-영어발표/포스터-국문발표 가능) |
| 제목 |
Preparation and Release Behavior of Ketoprofen-Encapsulated Polyoxalate Microspheres |
| 초록 |
Ketoprofen is one of the propionic acid classes of nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic effects. Hydrophobic polyoxalate (POX) has been suggested for use in biodegradable medical devices such as H2O2-sensitive bioimaging probe and controlled release formulation. In this study, we developed ketoprofen-encapsulated POX microspheres by changing kind of solvents and conditions to prepare microsphere about drug content, PVA concentration, Mw of POX and solvent content. The inner and outer morphology and physicochemical properties of ketoprofen-encapsulated POX microspheres was characterized using SEM, XRD, DSC, FT-IR and HPLC. Through the study results, the release behavior can be effectively controlled by kind of solvent and the preparation conditions. This research was supported by the Brain Korea 21 PLUS Project, NRF. |
| 저자 |
이천중, 김수영, 차세롬, 김은영, 송정은, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
ketoprofen; microsphere; O/W method; polyoxalate (POX)
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| E-Mail |
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