| 초록 |
To reconstruct damaged tissues, some strategies using cells, scaffolds, and bioactive molecules have been explored. Numerous scaffolds have been prepared for the development of cell/scaffold systems. The immobilization of bioactive molecules [e.g., growth factor (G.F.)] onto scaffolds are considered as an essential requirement for enhance tissue regeneration. In recent, the regulation of release rate of the bioactive molecules from matrices has been also gained increasing interest for more sophisticated target tissue regeneration. In this study, we developed porous beads with different surface pore size (micro, nano, and non-pore) which may control the release pattern of bioactive molecules by the different permeation rate of bioactive molecules through the pores. Their morphology, G.F. loading amount and release profiles were investigated. And the optimum environment for differentiation of stem cell into target cell type by the G.F. with different release patterns was also evaluated. |
