| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 가을 (10/10 ~ 10/12, 경주컨벤션센터) |
| 권호 |
43권 2호 |
| 발표분야 |
대학원생 구두발표(발표15분) |
| 제목 |
Sub-nanogram Level Biomarker Capturing by Nanoporous Microneedles |
| 초록 |
Minimally invasive microneedle (MN) patches have shown its potential for the rapid detection of biomarkers toward diagnostic point-of-care testing. However, achieving sufficient detection sensitivity for target molecules is a significant challenge. Here we present a highly sensitive detection platform using nanoporous MNs, enabling a rapid capturing of biomarkers present at sub-nanogram level. The uniform nanopore arrays on the MN surface was prepared by a controlled anodization process and then the nanoporous MNs were functionalized by the immobilization of biomarker-specific antibody to detect a target biomarker based on an immunoassay method. The bio-functionalized MN patch showed a rapid capture of estradiol known as a biomarker of preeclampsia following 1 min incubation time. The nanoporous MN platform can be employed to detect diverse biomarkers including metabolites and proteins and could be integrated into a handheld system for point-of-care clinical diagnostics. |
| 저자 |
강예은, 성금용, 임상구, 이예찬, 양승윤
|
| 소속 |
부산대 |
| 키워드 |
Biosensor; Microneedle; Preeclampsia
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| E-Mail |
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