| 학회 | 한국공업화학회 |
| 학술대회 | 2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 23권 2호 |
| 발표분야 | 우수논문(구두)_박사과정 |
| 제목 | Hyaluronic Acid Microgel for Sustained Delivery of Therapeutic Proteins |
| 초록 | Short half-life and fast clearance of protein drugs induce frequent administration for therapeutic efficiency, causing physiological burdens and bacterial infections. To achieve long term delivery of therapeutic proteins, a novel injectable protein loaded hyaluronic acid microgel (HA microgel) via thiol-ene click chemistry was developed. The crosslinking density (0.4~12.6 kPa) and gelation time (41~165 sec) of HA hydrogels could be controlled at various polymer concentration. The spherical shape and size (2.5~4 µm) of HA microgel were analyzed by DLS and FE-SEM. The extended release pattern of a model protein from HA microgels was evaluated; 62.3% for 1 month with burst release. Moreover, this carrier was cytocompatible against hDFBs by WST-1. From the obtained results, we can suggest a novel promising microgel as a long term sustained delivery carrier for a variety of protein drugs. Acknowledgements: 2018M3A9B5021319, NRF-2018R1A2B2004529 |
| 저자 | 이시민, 박기동, 손주영 |
| 소속 | 아주대 |
| 키워드 | Microgel; Protein drug; Long term delivery |
