| 학회 |
한국공업화학회 |
| 학술대회 |
2021년 가을 (11/03 ~ 11/05, 대구 엑스코(EXCO)) |
| 권호 |
25권 2호 |
| 발표분야 |
포스터-생체재료 |
| 제목 |
Tissue Engineered Transplantable Nano-Constructs for Tendon Regeneration |
| 초록 |
Tendon ruptures are one of the most common injuries of orthopedic pain. Despite the recent advances in surgical techniques and improved clinical outcomes of arthroscopically tendon repair, complete functional recovery—without retear—of the tendon through TBI regeneration remains a key clinical goal to be achieved. Inspired by the highly organized nanostructured extracellular matrix in tendon tissue, we propose herein a tissue engineered nano-construct for tendon regeneration. When compared with two currently used strategies (i.e., transosseous sutures and stem cell injections), our nano-construct facilitated more significant healing of all parts of the TBI (i.e., tendon, fibrocartilages, and bone) in both rabbit and pig RCT models owing to its enhancements in cell proliferation and differentiation, protein expression, and growth factor secretion. Overall, our findings demonstrate the high potential of this transplantable nano-construct for clinical repair of tendon rupture. |
| 저자 |
권용현1, 김우찬1, 박선호1, 김효성1, 김명선2, 김장호
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| 소속 |
1Chonnam National Univ., 2Chonnam National Univ. Medical School & Hospital |
| 키워드 |
tissue engineered nano-construct;tendon-to-bone interface; tendon regeneration |
| E-Mail |
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